ECE2019 Poster Presentations Thyroid 3 (74 abstracts)
Beneficial and fast impact of intravenous levothyroxine therapy on the lipid profile in severe hypothyroid patients
Pablo Trincado Aznar 1 , María Martínez García 1 , Beatriz Lardiés Sánchez 2 , María Elena López Alaminos 1 , Almendra Alvarado Rosas 1 , Isabel Azcona Monreal 1 , Patricia de Diego García 1 & Concepción Zapata Adiego 1
1Hospital Universitario Miguel Servet, Zaragoza, Spain; 2Hospital Obispo Polanco, Teruel, Spain.
Introduction: Abnormalities of lipid metabolism and arterial hypertension occur with increased frequency in hypothyroidism and are associated with a higher risk of premature atherosclerotic vascular disease. Therefore, a vigorous lipid lowering treatment seems mandatory, including quickly restoration of thyroid function, to reduce vascular risk. We evaluate benefits on lipid profile after intravenous thyroxine treatment in severe hypothyroid patients at three and thirty days.
Material and methods: Our retrospective study includes 70 consecutive severe hypothyroid patients (mean TSH of 104.1 mUI/L (±34.6)) treated with intravenous levothyroxine from 2004 to 2018 at our institution with a mean dose of 433.3 micrograms in two days and afterwards treated orally with a standard replacement dose. Total cholesterol, LDL-c, HDL-c, triglycerides, creatinine and CPK were measured on days 2–3 and 30 after treatment. No extra lipid lowering agents were used during the study. Data were analyzed with the Statistical Package for Social Science (SPSS), version 20.0 (SPSS Inc., Chicago, IL).
Results
| Mean (+ SD) at admission | Mean (+ SD) at 2°-3° day | Mean (+ SD) at 30 days | P | |
| Total Cholesterol (mg/dl) | 273.5 (+93.1) | 231.13 (+86.1) | 175.6 (+42.2) | <0.05 |
| HDL-c (mg/dl) | 65.7 (+29.7) | 57.4 (+21.1) | 50.78 (+14.1) | <0.05 |
| LDL-c (mg/dl) | 166.8 (+60.3) | 143.6 (+57.8) | 104.5 (+36.1) | <0.05 |
| Triglycerides (mg/dl) | 151.24 (+28.2) | 130.2 (+31.9) | 106.3 (+50.5) | <0.05 |
| Creatinine (mg/dl) | 1.14 (+0.4) | 1.1 (+0.3) | 1.0 (+0.4) | <0.05 |
| CPK (U/L) | 805.7 (+119.2) | 453.7 (+59.6) | - | <0.05 |
| Mean (+ SD) at admission | Mean (+ SD) at 2°-3° day | Mean (+ SD) at 30 days | P | |
| Total Cholesterol (mg/dl) | 273.5 (+93.1) | 231.13 (+86.1) | 175.6 (+42.2) | <0.05 |
| HDL-c (mg/dl) | 65.7 (+29.7) | 57.4 (+21.1) | 50.78 (+14.1) | <0.05 |
| LDL-c (mg/dl) | 166.8 (+60.3) | 143.6 (+57.8) | 104.5 (+36.1) | <0.05 |
| Triglycerides (mg/dl) | 151.24 (+28.2) | 130.2 (+31.9) | 106.3 (+50.5) | <0.05 |
| Creatinine (mg/dl) | 1.14 (+0.4) | 1.1 (+0.3) | 1.0 (+0.4) | <0.05 |
| CPK (U/L) | 805.7 (+119.2) | 453.7 (+59.6) | - | <0.05 |
Conclusions: Lipid profile in severe hypothyroid patients shows a fast response in 48 hours to intravenous levothyroxine with marked improvement in all parameters.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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