Endocrine Abstracts

Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism in the world with iodine deficiency and its incidence is 0.3–1.5 per 1,000. The aim of this study is to retrospectively evaluate the demographic characteristics, clinical and laboratory findings of the patients with HT who applied to our endocrinology outpatient clinic. The findings were compared with the control group who had hypothyroidism with negative thyroid autoantibodies. For this purpose, a total of 1009 patients with the diagnosis of 788 HT and 221 control groups were included in the study. Age, gender, age of diagnosis, duration of disease, initial clinics of patients (hypothyroidism, euthyroidism, thyrotoxicosis) and thyroid antibody positivity (anti-TPO, anti-Tg, TSH receptor antibody (TRAb)), thyroid US findings were reviewed. If thyroid fine needle aspiration biopsy (TFNAB) and/or thyroidectomy was performed, pathology reports were examined. The patient group was between 18 and 89 years (48.22±14.07) and the control group was between 18 and 79 years (48.85±14.51). 90% of the patients were female (n=709) and 10% were male (n=79); 86.9% of the control group were female (n=192) and 13.1% (n=29). At admission, 74.6% hypothyroidism, 17.3% euthyroidism and 8.1% hyperthyroidism were reported in HT group. In the evaluation of USG, heterogeneous echo was observed almost completely in the HT group, while in the control group 27.1% of the patients had normal echo. In the HT and control groups, approximately half of the patients had nodules at any time during follow-up. The most common cytology results of TFNAB were benign cytology in both groups, and the most common malignant result was papillary cancer (% 3.34-3%). When the results of thyroidectomy were evaluated, it was found that papillary cancer was the most frequent and no significant difference was found between the two groups. The only significant difference among the accompanying diseases was found in Diabetes Mellitus (P=0.001). There was no statistically significant increase in any of the malignancies (colon, ac, breast, and ovarian).