Endocrine Abstracts

Introduction: Omentin is a visceral fat tissue adipokine which regulates metabolism (insulin sensitivity) and presents an anti-inflammatory activities, by lowering C-reactive protein concentration, in obesity and diabetes mellitus type 2. Polycystic ovary syndrome is the most common endocrinopathy in women of childbearing age. One of the major disorders in the PCOS metabolic phenotype is obesity and hyperinsulinaemia. The anthropometric indicators are useful tools for carbohydrate and lipid profiles disorders.

Aim: The aim of the study was to estimate the omentin serum concentration and its relationship with the new anthropometric indicators (BAI, VAI, ABSI, BRI and LAP) and inflammation parameters (insulin, C-reactive protein) in PCO-S.

Material and methods: The study included 29 women diagnosed with PCO-S according to Rotterdam criteria and hospitalized in Endocrinology City Hospital in Piekary in 2015–2018. Anthropometric and biochemical parameters were used to calculate: BAI, VAI, ABSI, BRI and LAP. Blood pressure was regularly measured. PCO-S patients blood was centrifuged and the omentin serum concentration was determined in duplicates by ELISA method. Intra-assay variation was 4.1% and inter-assay – 4.8%. Statistically significant value P<0.05 was assumed.

Results: In the examined group of women the average age was 27 years (±6,3), body mass 78kg (±22.9), height 165 cm (±5.7), waist circumference 91 cm (±19.5) and hip circumference 108 cm (±13.5). The average omentin serum concentration was 261ng/ml (±6,3). Omentin serum concentration was statistically higher in PCO-S patients with lower insulin concentration (P<0.05, r=−0.5). There was no significant correlation between omentin serum concentration and C-reactive protein concentration. Omentin serum concentration correlated negatively with BAI (P<0.05, r=−0.6), BRI (P<0.05, r=−0.6) and LAP (P<0.05, r=−0.4) values. There was observed significant correlation between omentin serum concentration and ABSI value in the examined women (P<0.05, r=+0.4). Significant correlation between omentin serum concentration and VAI value was not foud. The interesting observation was the strong negative correlation between omentin serum concentration and diastolic pressure value in PCO-S women (P<0.05, r=−0.6). The observed results requires further studies to explain the possible meaning.

Conclusion: Omentin concentration could be a functional tool to estimate metabolic disorders and inflammation risk in women with PCO-S. Further studies, involving a larger group of PCO-S women, to confirm these conclusions are needed.