ECE2019 Poster Presentations Calcium and Bone 1 (60 abstracts)
Verified data on parathyroid hyperplasia incidence not related to primary hyperparathyroidism in persons exposed to ionizing radiation
Oleksii Kaminskyi 1 , Olga Kopilova 1 , Dmitrii Afanasyev 1 , Konstantin Loganovskyi 1 , Viktoria Talko 1 , Irina Muravyova 1 , Irina Chikalova 1 , Olena Tepla 1 & Iryna Kiselova 2
1State Institution National Research Centre for Radiation Medicine of NAMS of Ukraine, Kiev, Ukraine; 2City Clinical Endocrinology Center, Kiev, Ukraine.
During the Chernobyl nuclear power plant accident (ChNPPA) a mixture of radioactive isotopes, mainly the iodine and cesium, were released, which through inhalation and food, and in some cases along with external exposure had affected the hormone-producing cells of endocrine system. Within days and months after the accident, the thyroid and parathyroids accumulated a significant amount of these isotopes with thyroid gland becoming a secondary emitter, which further increased the exposure of parathyroids. Therefore, we expect some significant disorders in parathyroid gland system in the late period of the ChNPPA. We have developed and improved the method of ultrasound screening of parathyroids, which increases the efficiency of their visualization. We have conducted a survey of 1,534 individuals attributed to the ChNPPA survivors exposed to ionizing radiation. Thirty-two years after irradiation the parathyroid hyperplasia not related to primary hyperparathyroidism was detected on average in 34.4% of cases, namely in 28.8% of the ChNPPA clean-up workers, 71.5% evacuees from the 30-kilometer contaminated zone around the Chernobyl nuclear power plant, 41.5% residents of areas under a radiological control, 45.5% residents of Kiev city and Kiev region, and 33.3% subjects irradiated in prenatal period of life. Thus, there is a high prevalence of parathyroid hyperplasia among the population of Ukraine exposed to a range of radiation doses from the tropic iodine, cesium and strontium isotopes, including the low-dose prolonged irradiation. In most cases there were no abnormalities in serum concentration of parathyroid hormone and ionized calcium. Deficiency or lack of vitamin D was an additional factor involved in this situation. Our immediate task is to study the incidence of functional disorders of parathyroid hormone secretion and relation of parathyroid hyperplasia on vitamin D deficiency, as well as to identify any comorbid disorders in the vulnerable population groups.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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