ECE2019 Guided Posters Obesity (12 abstracts)
Dietary inflammatory index is differently associated with ectopic fat depots in overweight and obese adults
Eleonora Poggiogalle 1 , Carla Lubrano 1 , Federica Luisi 1 , James R Hebert 2 , Nitin Shivappa 2 , Michele Di Martino 1 , Lucio Gnessi 1 , Stefania Mariani 1 , Andrea Lenzi 1 & Lorenzo M. Donini 1
1Sapienza University, Rome, Italy; 2University of South Carolina, Columbia, USA.
Introduction: In overweight and obesity energy unbalance is responsible for the accumulation of ectopic fat. Excess energy and metabolic alterations, namely insulin resistance, may favor ectopic fat depositions. However, the role played by dietary factors, especially the pro-inflammatory properties of dietary patterns, in ectopic fat storage is not thoroughly understood. The aim of our study was to investigate the association between the Dietary Inflammatory Index (DII) and different ectopic fat depots.
Methods: Participants were recruited among subjects admitted to the High Specialization Centre for the Care of Obesity (CASCO), at the Sapienza University, Rome, Italy. Inclusion criteria were: age 18-75 years, body mass index (BMI) ≥ 25 kg/m2. The intrahepatic lipid content (IHL) and the intramyocellular lipid content (IMCL) were assessed through magnetic resonance spectroscopy, whereas intermuscular adipose tissue (IMAT, as adipose tissue between skeletal muscle bundles and beneath the muscle fascia), visceral and subcutaneous adipose tissue (VAT and SAT) were evaluated by magnetic resonance imaging. 3-day dietary records were administered and analyzed by a registered dietician. The DII score (adjusted for energy density) and the HOMA-IR were calculated. High-sensitivity C-reactive protein (hs-CRP) was measured.
Results: 77 subjects (males: 18%) were included (age: 47.7±13.5 years, BMI: 37.1±5.7 kg/m2). The DII score was positively associated to IHL (beta: 0.221, SE: 0.101, P=0.03) and IMAT (beta: 0.140, SE: 0.066, P=0.04) after adjustment for age, sex, hs-CRP levels, HOMA-IR, and VAT. No associations emerged between DII score and IMCL or VAT, or SAT.
Conclusion: A more pro-inflammatory dietary pattern is associated with fatty liver, and intermuscular adipose tissue, but it does not seem to affect intramyocellular lipid storage.
Volume 63
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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