Endocrine Abstracts

Introduction: Ramadan is the 9th month of the Islamic calendar, where Muslims are fasting from dawn to sunset. The diabetic patient is exposed to multifactorial risks. Few studies have examined the effect of Ramadan on non-fasting people. The objective of our study was to determine the effects of the fast on the metabolic profile of non-gambling diabetic patients.

Patients and methods: Prospective study including 50 non-fasting patients recruited within the Endocrinology department during the month of Ramadan 2018. The clinical and biological parameters were on two periods before Ramadan (T0) and three weeks after the end of Ramadan (T2). Statistical Analysis by Spss version 25.0.

Results: The characteristics of our patients were a mean age of 52.56±11.51 years, a sex ratio of 1.08 H/F, a family life of 82.4% and a low level of education in 37.3. %. The average body mass index of 33.45±7.5 kg/m². Average seniority of 8.72±7.74 years, average HbA1c of 7.9%. The degenerative complications were: retinopathy (37.3%), nephropathy (21.6%), neuropathy (25.5%), dyslipidemia (31.4%), coronary artery disease (7.8%). The dietary survey revealed an average caloric intake of 1743.4±425.86 Kcal/J. There was no difference between the mean weight of patients before and after Ramadan at 86.4±19.35 kg, nor any change in blood pressure. The mean blood glucose level was stable at 1.51±0.46 g/l. An LDL decrease of 0.2 g/l and an increase of 0.1 g/l. In addition, no difference was noted between serum calcium, proteinemia, albuminemia and serum uricemia. Treatment regimens before Ramadan were monotherapy (23.5%), dual therapy (37.3%), three (2%), bedtime (19.6%), diet alone (4%) and after Ramadan monotherapy (60%), biotherapy (35%) and diet alone (5%). The use of hospitalization was necessary in 12 cases (24%), of which 3 were admitted to intensive therapy.

Conclusion: According to these results, the fasting of the month of Ramadan significantly alters the glycemic balance and the lipid balance in non-fasting type 2 diabetics. Hence the interest of sensitizing the diabetic and the practitioner of the importance of pre-Ramadan consultation.