Endocrine Abstracts

Abstract Unavailable....

Background: Thyroid peroxidase antibodies are associated with increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate levothyroxine could reduce such adverse outcomes.Methods: We conducted a double-blind, placebo-controlled trial to investigate whether levothyroxine treatment would increase live birth rates among euthyroid women with thyroid peroxidase antibodies and a history of miscarriage or inferti...

Around half of expectant mothers worldwide are overweight or obese and 20% smoke. Exposure to such factors during fetal life is linked to diseases including obesity, cardiovascular disease, and behavioural disorders. Because thyroid hormones control fetal metabolism, cardiac output and brain development, altered fetal thyroid signalling can contribute to future disease. We examined the impact of maternal smoking and overweight/obese (body mass index, BMI, ≥25) on the thy...