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Endocrine Abstracts (2019) 63 P773 | DOI: 10.1530/endoabs.63.P773

ECE2019 Poster Presentations Thyroid 2 (70 abstracts)

Evaluation of oxidative stress parameters in subacute thyroiditis patients

Murat Dağdeviren 1 , Arzu Or Koca 1 , Tolga Akkan 1 , İhsan Ateş 2 , Salim Neşelioğlu 3 , Özcan Erel 3 & Mustafa Altay 1


1University of Health Science, Keçiören Health Administration and Research Center, Department of Endocrinology and Metabolism, Ankara, Turkey; 2University of Health Science, Numune Health Administration and Research Center, Department of Internal Medicine, Ankara, Turkey; 3University of Yıldırım Beyazıt, Department of Medical Biochemistry, Ankara, Turkey.


Objective: The aim of our study was to determine whether there is a relationship between oxidative stress parameters and subacute thyroiditis.

Material and methods: The study included 55 subacute thyroiditis patients and 30 healthy volunteers. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON) and thiol/disulfide homeostasis parameters were measured by a novel and automated assay in the patient and control groups.

Results: TAS, TOS, oxidative stress index (OSI: TOS/TAS) and PON values were similar in both groups (P>0.05). Native thiol (NT) and total thiol (TT) values were significantly higher in the control group (P<0.001). Disulfide/native thiol (DS/NT) and disulfide/total thiol (DS/TT) levels were higher in the subacute thyroiditis group. Native thiol/total thiol (NT/TT) levels were significantly higher in the control group (P=0.02). When the all participants were evaluated, there was a negative correlation between white blood cell (WBC), neutrophil counts and sedimentation levels and only NT and TT (P <0.05). CRP levels were negative with NT, TT and NT/TT levels; there was a positive correlation with DS/NT and DS/TT levels (P <0.05). In the subacute thyroiditis group, only CRP levels were correlated with TAS (r=−0.55, P=0.004) and OSI (r=0.451, P=0.24) levels.

Conclusion: It was first shown that there may be a relationship between subacute thyroiditis and oxidative stress. Oxidative stress may also be the cause of pathophysiology in subacute thyroiditis.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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