ECE2019 Poster Presentations Reproductive Endocrinology 2 (39 abstracts)
Serum anti-Müllerian hormone is significantly associated with higher luteinizing hormone level in polycystic ovary syndrome
Nicoleta Baculescu 1, , Laura Leonte 2 , Serban Radian 1, , Monica Gheorghiu 1, , Andrei Muresan 1 , Bianca Biban 1 , Maria Baleanu 1 , Florin Grigorescu 2, & Catalina Poiana 1,
1C.I. Parhon National Institute of Endocrinology, Bucharest, Romania; 2Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; 3IURC, UMR-204 NUTRIPASS, University of Montpellier, Montpellier, France.
Background: Recent data highlight the role of anti-Müllerian hormone (AMH) to trigger the neuroendocrine abnormalities involving GnRH and secretion of gonadotropins in polycystic ovary syndrome (PCOS).
Aim: To study factors significantly correlated with neuroendocrine dysfunction in PCOS, with focus on AMH.
Subjects and methods: We performed a cross-sectional study in 137 patients with PCOS selected by Rotterdam 2003 criteria and 166 controls age matched, recruited at the National Institute of Endocrinology, Bucharest, Romania. Clinical and biochemical parameters, including BMI, fasting glucose and insulin, serum LH, FSH, AMH and TT were determined and the values are expressed as mean ±S.E.M. HOMA-IR was calculated to quantify insulin resistance.
Results: LH values were 11.24±0.79 UI/l in PCOS and 5.97±0.41 UI/l in controls; FSH values were 6.23±0.22 UI/l in PCOS and 7.65±0.53 UI/l in controls; and AMH was 69.16±3.29 pmol/l in PCOS and 25.24±2.93 pmol/l in controls. LH and AMH were significantly higher (P< 0.0001, P< 0.0001) and FSH significantly lower (P=0.03) in PCOS than in controls. In PCOS, LH was positively correlated with AMH (P< 0.0001) and TT (P=0.0006) while BMI (P=−0.1009), fasting-Ins and HOMA-IR were not significantly correlated with LH in these patients. In stepwise linear regressions including as effects AMH, TT, BMI, fasting-Ins or HOMA-IR and age, AMH remained a significant independent predictor for LH values in PCOS (P=0.0002). FSH had no significant correlations in PCOS. There were no significant correlations for gonadotropins in controls.
Conclusions: These data reveal AMH as a significant positive independent predictor for higher LH values in PCOS and support the role of AMH in maintaining high levels of LH in PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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