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Endocrine Abstracts (2019) 63 P277 | DOI: 10.1530/endoabs.63.P277

1Carol Davila UMPh, Bucharest, Romania; 2CI. Parhon National Institute of Endocrinology, Bucharest, Romania; 3Bagdasar Arseni Emergency Hospital, Neurosurgery Department, Bucharest, Romania.


Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.

Objective: To study the postsurgical evolution of craniopharyngioma in adults after total or incomplete surgical resection.

Material and methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest between 1998 and 2018.

Results: A total of 60 patients (39.62±15.6 years-old) diagnosed with craniopharyngioma were included. All underwent initial surgery (68.3% transcranial, 31.7% transsphenoidal approach). Gross total resection (GTR) was achieved in 21 cases (35%), in all the others maximal resection was attempted (non-GTR). Surgery led to anosmia (in 2 cases), CSF leak (3 cases), subdural hematoma (2 cases). After surgery 13 cases (21.66%) had cognitive impairment (2 with GTR, 11 with non-GTR), 14 (23.3%) had hypothalamic syndrome (diurnal sleepiness, appetite and memory dysfunction- present in 1 case with GTR, 13 with non-GTR), 27 cases (45%) reported lethargy (7 GTR, 20 non-GTR), 24 (40%) complained of headaches (6 GTR, 18 nonGTR). All these complications were significantly more frequent in cases with incomplete tumor resection compared to those with GTR: P=0.000; 0.000; 0.036 and 0.009, respectively.

Conclusions: Craniopharyngioma is a tumor associated with very significant morbidity. GTR should only be attempted when a low risk of neurologic injury is considered; for the rest of the cases limited tumor resection followed by irradiation of the remnant might be the safest approach.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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