Endocrine Abstracts

Introduction: Different studies indicated the possible association between celiac disease and Helicobacter pylori (HP) infection, although this evidence is not consistently accepted. The aim of our study was to determine whether HP infection and celiac disease were associated among patients undergoing upper gastrointestinal endoscopy.

Methods: Between January 2017 and June 2018, patients undergoing upper gastrointestinal endoscopy with both gastric and duodenal biopsies were included for analysis. The diagnosis of celiac disease was based on positive serology and the presence of villous atrophy at duodenal biopsy. Antrofundic biopsies were performed looking for HP infection.

Results: Overall, 140 patients divides in 85 women and 55 men were enrolled. The median age was 28.7 years. Seventy of them (50%) had a celiac disease. The prevalence of HP infection among celiac disease patients was 14.5%, compared to 50% in non-celiac patients (P=0.03). In patients with celiac disease and HP infection, total flattening of duodenal fold in upper gastrointestinal endoscopy was found in 45% of patients, compared to 55% of patients without HP infection (P=0.8). Total villous atrophy was observed in 23% of patients with HP infection compared to 28% of patients without HP infection (P=0.7).

Conclusion: Our study revealed that HP infection was less frequent in celiac disease. Amon gpatients with celiac disease, endoscopic markers of villous atrophy and histological damage severity were similar between patients with and without HP infection.