ECE2019 Poster Presentations Environment, Society and Governance (15 abstracts)
Observational study on the cardio-metabolic effects of a night shift on internists
Stella Bernardi 1, , Barbara Toffoli 3 , Tommaso Ferretti 1 , Morena Francica 1 , Elena Ghirigato 1 , Matteo Rovina 2 , Veronica Calabrò 2 , Elisabetta Stenner 2 , Fabiola Giudici 1 & Bruno Fabris 1,
1Department of Medical Sciences, University of Trieste, Trieste, Italy; 2Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy; 3IRCCS Burlo Garofolo, Trieste, Italy.
Introduction: Shift work has been associated with increased cardiovascular morbidity and mortality. Several studies have demonstrated that shift work has an effect on cardiovascular and metabolic health. Most of these studies have compared different groups of shift workers to nonshift workers. By contrast, the present work aimed to evaluate the cardio-metabolic effects of night shifts on the same group of internists as they changed type of duty. In particular, we focused on blood pressure and dipping status, as well as the levels of glucose, insulin, cortisol, and proinflammatory mediators.
Methods/design: A total of 14 internists working rotating shifts in a teaching Hospital were included in the study. Subjects with children aged less than 3 years and/or subjects with history of diabetes and cardiovascular disease were excluded from the study. Medical history, general and anthropometric parameters were collected at baseline. Then, since internists worked either a day shift (from 0800 h to 1600 h) or a night shift (from 1600 h to 0800 h), we scheduled a first 24-hour ambulatory blood pressure monitoring (ABPM) starting at 8 am on the work day with the day shift and a blood sampling the day after, at 8 am (at fasting). Then, the same subjects underwent a second 30-h ABPM starting at 8 am on the work day with the night shift and ending at 1400 h after the night shift. In addition, a blood sample was taken at 8 am after the night shift (at fasting), in order to measure glucose, insulin, cortisol, CRP, and proinflammatory mediators. During the night shifts, the number of admissions, calls, and the total amount of steps were recorded.
Results: Among the internists recruited, the ratio M:F was 1:1. On average, the age of the participants was 38±3 years, their BMI was 24±0.8, and they had been working for 9±2 years. Our preliminary data show that blood pressure dipping status was significantly impaired when comparing the work day with the day shift to the work day with the night shift, being 14.13±1.39% and 4.30±1.53%, respectively (P<0.001). Also the dipping status of the resting period after the night shift was significantly impaired as compared to that after the day shift, being 6.86±2.77% and 14.13±1.39%, respectively (P<0.05).
Conclusion: Our preliminary data suggest that night shifts have significant effects on the cardio-metabolic health of workers.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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