Endocrine Abstracts

Introduction: Unbalanced diabetes mellitus predisposes to bacterial and fungal infections especially candidiasis. Candidiasis can have several localizations including digestive, genitourinary or mucocutaneous. The purpose of this work was to analyze the characteristics of candidiasis in all these forms in the patient.

Materials and Methods: Descriptive cross-sectional study from January 2012 to December 2018, including 307 diabetic patients presenting with candidiasis and hospitalized in the endocrinology department of the Ibn ROCHD University Hospital of Casablanca. Collection of patient data was done from medical records. Oesogastroduodenal fibroscopy confirmed the diagnosis of gastrointestinal candidiasis. The statistical analysis was done with the software Epiinfo.7

Results: The mean age of our patients was 45.04 years (15–80), with a female predominance of 67.75%. Diabetes was type 2 in 204 patients with an average seniority of 6.40 years ± 5.29 and an average BMI of 27.94. The average glycemic level was 2.92 g/l and that of HbA1c was 10.12%. Candidiasis occurred in the wake of an inaugural ketosis in 5 patients, diabetic ketoacidosis in nine patients, major hyperglycemia in seven patients, chronic glycemic imbalance in 162 patients and in the wake of ketosis in 124 patients. It was genital in 149 patients or 48.53% (1balanite, vulvitis and vulvo-vulvitis vulvitis), oral in 115 cases or 37.45%, cutaneous in 43 cases or 14% affecting large folds, digestive in 21 cases or 6.84% and urinary in 6 cases or 1.95%. The majority of mycological samples isolated candida Albicans (80.36%) followed by candida Glabrata (19.64%). No other favorable factors have been found. Therapeutically, all our patients received antifungal treatment either by the general route (32.57%) or by the local route (67.42%). The evolution has been good in all cases.

Conclusion: Our study confirms that diabetes is an implicated factor in the occurrence of candidiasis so obtaining a glycemic balance would be necessary to prevent the occurrence of candidiasis