Endocrine Abstracts

Introduction: Hyperuricemia is associated with an increase in cardiovascular risk and complications of type 2 diabetes (1). The aim of this study is to establish a possible link between lipid profile and hyperuricemia.

Method: A total of 321 patients with type 2 diabetes were included in our study. Clinical and par clinical data were collected from patients’ medical records. The lipid profile includes low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride (TG) and total cholesterol (TC).

Results and discussion: The mean age of the population was 58±11.36. The mean body mass index (BMI) was 27.9 kg/m²±6.4. Data analysis showed: A positive and statistically significant correlation between TG and uric acid level (P=0.002). HDL cholesterol was inversely correlated with uric acid levels (P=0.001). however, there was no correlation between LDL and uric acid. The results of our study illustrate the strong association between uric acid increase and lipid disorder in diabetic type 2 suggesting a crucial role of uric acid in the regulation of dyslipidemia (2).

Conclusion: Previous studies have highlighted the intricacy of mechanisms of the pathogenesis of hyperuricemia and dyslipidemia. Thus, when establishing the diagnosis of hyperuricemia, coexisting dyslipidemia should be suspected. On the other hand, the management of hyperuricemia can help control dyslipidemia in patients with Type 2 diabetes (3).

Bibliography: 1. Alderman, and all, J.S., 2004. Serum uric acid: a cardiovascular risk factor? Ther. Umsch., 61(9):547–552. [doi: 10.1024/0040-5930.61.9.547]. PubMed CrossRef Google Scholar.

2. Yili Xu and all, Published: October 24, 2013: Hyperuricemia as an Independent Predictor of Vascular Complications and Mortality in Type 2 Diabetes Patients: A Meta-Analysis https://doi.org/10.1371/journal.pone.0078206

3. Jiao Wang and all: Prevalence and Determinants of Hyperuricemia in Type 2 Diabetes Mellitus Patients with Central Obesity in Guangdong Province in China.Asia Pacific Journal of Clinical Nutrition 2013/11/05, P46–54.