ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 2 (100 abstracts)
Endocrinopathies and diabetes: cardiovascular risk assessment
Marwa Khiari 1 , Ibtissem Ben Nacef 2 , Imene Rojbi 2 , Nadia Mchirgui 2 , Youssef Lakhoua 2 & Karima Khiari 2
1National Institute of Nutrition, Tunis, Tunisia; 2Endocrinolgy Department, Charles Nicoles Hospital, Tunis, Tunisia.
A large number of endocrine pathologies can be associated to abnormalities in carbohydrate tolerance up to diabetes. The latter participates in the high risk of cardiovascular morbidity and mortality during these pathologies. The aim of our study was to assess the cardiovascular risk in a diabetic population suffering from an endocrine pathology. This is a retrospective study conducted in the department of endocrinology at Charles Nicolle Hospital involving 54 patients hospitalized between 1985 and 2015. Our population includes diabetic patients: 22 cases of Cushing’s syndrome, 12 of acromegaly, 09 of pheochromocytoma and 11 of primary hyperaldosteronism. The average age of our population was 44.85±12.74 years old. The majority were female (72.2%). 27.8% were smokers. Obesity was present in 37% of cases. Almost all of our patients had high blood pressure (92.6%). The lipid profile showed hypercholesterolemia in 48.1% of patients, hypoHDLemia in 45.5% and hypertriglyceridemia in 53.8%. After healing of endocrinopathy, we found a remission of diabetes in 37% of cases. High blood pressure disappeared in 33.3%. Total cholesterol and HDL cholesterol were significantly improved (P=0.001 and P=0.05). On the other hand, the triglycerides have not been modified. Patients suffering from endocrinopathy are at high cardiovascular risk. Diabetes increases this risk and increases cardiovascular morbidity. The healing of endocrinopathy significantly improves the cardiovascular prognosis of these patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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