ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 1 (104 abstracts)
Metabolic health is strongly predicted by free Testosterone and SHBG levels in non-obese postmenopausal women
Eleni Armeni 1 , Stavroula A Paschou 1 , Areti Augoulea 1 , Dimitrios Rizos 2 , George Kaparos 3 , Anastasia Soureti 1 , Iliana Karagouni 1 , Georgios Georgiopoulos 2 , Kimon Stamatelopoulos 2 , Nikolaos Syggelos 1 & Irene Lambrinoudaki 1
1Second Department of Obstetrics and Gynecology, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 2Vascular Laboratory, Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece; 3Biochemical Laboratory, Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Introduction: Ovarian senescence and fluctuating levels of sex hormones is associated with metabolic derangement and central obesity. The aim of this study was to explore the association between serum levels of sex hormones and metabolic health in non-obese postmenopausal women.
Patients and methods: This cross-sectional study included a total of 457 non-obese postmenopausal (BMI <30 kg/m2) women, retrieved from the Menopause Clinic of Aretaieio Hospital, Medical School, National and Kapodistrian University of Athens. Participating women were classified into metabolically obese, if they fulfilled at least 3 diagnostic criteria of the International Diabetes Federation, used for the definition of Metabolic Syndrome (MONW), while women with less than 3 criteria were defined as metabolically healthy (MHNW).
Results: The prevalence of metabolic health was evident in 80.8% of non-obese women, while metabolic obesity was evident in 19.2% of women. We observed a significant difference in levels of sex hormones between obesity phenotypes (MONW vs MHNW: SHBG 55.8±30.4 vs. 76.7±32.8, P-value<0.001; FAI 3.14±1.82 vs 2.29±1.54, P-value<0.001; FEI 0.157±0.153 vs 0.119±0.127, P-value=0.036; E2 17.9±13.7 vs 27.8±44.4, P-value=0.047). Levels of testosterone were not associated with phenotypes of metabolic health. Multivariate logistic regression analysis showed significant predictors of the MONW phenotype, in models adjusted for age and YSM (years since menopause): i) SHBG levels (OR 0.979, 95% CI: 0.967 to 0.990); ii) FAI levels (OR 1.339, 95% CI: 1.121 to 1.599, P-value=0.001). The multivariate analysis showed that the association between FEI, E2 and the MONW phenotype was lost following adjustment for age and YSM.
Conclusions: This study provided evidence that metabolic obesity is associated with higher levels of free testosterone and lower levels of SHBG, irrespectively of age and time since menopause, in non-obese postmenopausal women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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