Endocrine Abstracts

There is growing evidence that platelet indices correlate with functional status of platelets and with the risk of cardiovascular events. In this study we aimed to assess clinical correlates of mean platelet volume (MPV) in patients with abdominal obesity from different age groups. We investigated 111 adults with abdominal obesity, not receiving antiplatelet therapy. Abdominal obesity was defined in accordance with IDF criteria (2006). Group 1 included 44 patients aged 26–45, group 2–67 patients aged 46–65. We evaluated clinical history, serum levels of lipid fractions, homocysteine, creatinine, eGFR, C-reactive protein, total and free testosterone (in men only), insulin, HOMA-IR index, and 25-hydroxyvitamin D. Mann-Whitney U-test and Spearmen’s correlation coefficient (rs) were used for statistical analysis. Groups were found to have no significant differences when compared on the basis of sex composition, BMI, waist-to-hip ratio, HOMA-IR index, platelet level, and MPV. In both groups MPV was not interconnected with age, BMI and eGFR. In group 1, MPV correlated positively with the level of C-reactive protein (rs=0.390, P=0.009) and negatively – with total testosterone (rs=-0.387, P=0.042) and free testosterone (rs=−0.637, P=0.001) in men. In group 2, MPV had the only negative correlation with the level of 25-hydroxyvitamin D (rs=−0.299, P=0.015). The results of the study suggest that different age groups of patients with abdominal obesity are characterized by different clinical determinants of MPV. In younger adults MPV is interconnected with C-reactive protein and testosterone levels (in men), while in people aged 46-65 it is significantly related to the level of 25-hydroxyvitamin D.