ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 1 (104 abstracts)
The relationship between glycated hemoglobin, postload blood glucose levels and non-hdl cholesterol among 75 gram oral glucose tolerance test applied women
Hilal Yönet Aslan 1 , Özlem Polat 1 , Ayşe Esen 2 , Evin Bozkur 2 , Betül Öndes Denizli 1 , Medine Şişman 1 , Hamide Pişkinpaşa 2 , Yasemin Şefika Akdeniz 2 , Sami Hatipoğlu 3 & Meral Mert 2
1Family Medicine, University of Health Science, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 2Endocrinology and Metabolism, University of Health Science, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey; 3Pediatry, University of Health Science, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey.
Aim: Diabetes and prediabetes become prevalent day by day, likewise their complications are also as important as they are. Lipid profile is also evaluated for cardiovascular diseases which are the major complications of diabetes and prediabetes. Non-HDL cholesterol has begun to be taken as one of the treatment goals, especially in diabetics, with respect to the recent dyslipidemia guidelines. The aim of this study is to compare non-HDL values in women with normal or impaired glucose tolerance or diabetes mellitus according to the results of 75 g oral glucose tolerance test (OGTT) and to analyse the relationship between 0- and 2- hour blood glucose values with HbA1c and non-HDL.
Materials and methods: Glucose, OGTT 0- and 2-hour blood glucose values, HbA1c, total cholesterol, triglyceride, HDL, LDL and non-HDL cholesterol results of 75 g OGTT applied women in Bakırköy Dr. Sadi Konuk Education and Research Hospital, were evaluated retrospectively. Patients were grouped according to OGTT results. The relationship of the parameters in each other for each group and the differences between groups were examined. Pearson correlation coefficient and, for ANOVA and Post-Hoc information Bonferroni test were applied as statistical methods.
Results: 34, 85 and 14 of 133 women were determined as normal, prediabetic and diabetic in our study group, respectively. For whole group, OGTT 0-hour variable was determined as 41% and 38.6% correlated with OGTT 2-hour and HbA1c, respectively; OGTT 2-hour variable was 36.5% correlated with HbA1c; HbA1c was 17.2% correlated with non-HDL positively and these were statistically significant. In diabetic group, non-HDL averages were found as significantly higher when compared to impaired glucose tolerance, statistically. In whole group, proportion of individuals who reached to target LDL values and non-HDL targets were 34.6% and 47.4%, respectively.
Conclusion: Glucose metabolism states of individuals should be determined and precautions should be taken to avert complications within the context of preventive medicine. The risk should be identified by evaluating lipid profile in the scope of cardiovascular diseases. Non-HDL cholesterol should be considered as secondary treatment target, especially for diabetics.
Keywords: Cardiovascular diseases, diabetes mellitus, HbA1c, non-HDL cholesterol, oral glucose tolerance test, prediabetes
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