Endocrine Abstracts

Aim of the study: To investigate osteoporosis features in elder patients in Moscow population.

Materials and Methods: It was a retrospective study, during which we analyzed the data of 192 outpatients (183 women and 9 men) admitted to Gerontology Research and Clinical Centre in 2018. In the focus of our attention was patients’ past medical history, such as any antiosteoporotic treatment received, vitamin D and Ca supplementations, any fractures in previous 5 years and T-criteria values assessed by DEXA-scan. The statistical analysis was performed using Prism 8 Version 8.0.1 (145). Statistically significant were differences with P< 0.05.

Results: Median age of the patients was 77 [73; 87] years. 20% of the patients had history of taking oral glucocorticoids. The prevalence of fractures in PMH was 82% (157 patients). With more detailed analyzing we found out that the number of patients with three and more fractures was quite high and was 89, so more than a half of the group with fractures. The most frequent localization of fracture was lumbar vertebras (53%), meanwhile radius fractures and other localization fractures were found in 27% and 20% of the cases respectively. The values of T-criteria for hip and spine according to DEXA-scans showed significantly lower T-criteria (P=0.04) for lumbar vertebras vs hip: Me −3.1 [−2.6; −3.6]. 50% of the patients did not receive any antiosteoporotic treatment; treated patients received bisphosphonates in most cases (63%, n=59), followed then by denosumab (18%, n=17) and teriparatide (9%, n=8). The adverse effects were much higher in BF group (90% of all cases). Patients receiving only Ca supplementation had approximately the same prevalence of fractures compared to patients with no Ca/Vit D supplementation, meanwhile patients receiving only vitamin D had significantly lower prevalence of fractures [P=0.045], and patients receiving Ca+VitD did not differ from only Vit D-group.

Conclusion: Vitamin D and combined supplementation is extremely important in prevention of fractures, meanwhile Ca alone does not have any protective effect. In severe osteoporosis the preference should be given to anabolic treatment for better results.