ECE2019 Poster Presentations Adrenal and Neuroendocrine Tumours 1 (60 abstracts)
Endocrine hypertension: before and after treatment of the endocrinopathy
Marwa Khiari 1 , Ibtissem Ben Nacef 2 , Imene Rojbi 2 , Karima Khiari 2 , M Jerbi 2 , Nadia Mchirgui 2 , Youssef Lakhoua 2 & Nejib Ben Abdallah 2
1National institute of Nutrition, Tunis, Tunisia; 2M8 Endocrine Department, Charles Nicoles Hospital, Tunis, Tunisia.
High blood pressure of endocrine origin remains a rare cause of hypertension. The interest of the research of endocrine hypertension lies in the severity of certain forms and its potentially curable and reversible nature, hence the interest of oriented screening. The aim of our work was to study the profile of endocrine hypertension among a population suffering from secondary diabetes. This is a retrospective descriptive study of 55 patients followed in endocrinology department of the M8 ward, Charles Nicole Hospital, Tunis between 1985 and 2015. Dysthyroidism was excluded. The average age of our population was 44.85±12.74 years with a female predominance of 72.2%. It included Cushing’s syndrome in 40.7%, acromegaly in 22.2%, pheochromocytoma in 16.7% and primary hyperaldosteronism in 20.4% of cases. Mean systolic and diastolic arterial pressures were 166.3±23.2 mmHg and 97.00±15.2 mmHg, respectively. Hypertension was severe in 31.5% and resistant in 13% of cases. It was controlled by tritherapy in 22.2%, dual therapy in 24.1% and monotherapy in 27.8% of cases. We did not find a correlation between the severity of hypertension and the baseline hormonal level. After remission of the underlying endocrinopathy, blood pressure was statistically improved in all cases. Antihypertensive treatment was even discontinued in 61.1% of patients with Cushing’s syndrome, 66.7% of acromegalic patients, 44.4% of patients with pheochromocytoma and 9.1% of patients with primary hyperaldosteronism. Endocrine hypertension is a severe but often curable form of high blood pressure. Associated with diabetes, it increases cardiovascular risk during endocrinopathies. It is therefore imperative to detect and balance it while waiting for the treatment of the underlying endocrinopathy.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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