ECE2019 Poster Presentations Adrenal and Neuroendocrine Tumours 1 (60 abstracts)
Effect of Glucocorticoid receptor antagonist administration in a Cushing’s syndrome model rat
Toshiro Seki 1 , Atsushi Yasuda 1 , Natsumi Kitajima 1 , Masami Seki 2 , Masayuki Oki 1 & Masafumi Fukagawa 1
1Tokai University School of Medicine, Kanagawa, Japan; 2Seirei Numazu Hospital, Shizuoka, Japan.
In Cushing’s syndrome (CS), hypercortisolemia due to cortisol-producing adrenal adenomas suppresses the hypothalamic-pituitary-adrenal (HPA) axis, so the normal adrenal tissue is atrophied without ACTH stimulation and its function impairs. As a result of surgical resection of cortisol-secreting adenoma, postoperative adrenal insufficiency occurs. Therefore, we thought that administering glucocorticoid receptor antagonist (mifepristone) in order to release suppression of HPA axis caused by hypercortisolemia enables early recovery of adrenal function due to stimulation of ACTH for normal adrenal glands. We thus compared adrenal function in a dexamethasone (DEX)-induced CS model rat (n=4) with or without mifepristone (MIF). In this study, MIF-treated rats demonstrated less suppression of plasma ACTH levels (55.13±15.87 pg/ml) and increased adrenal weight (26.3±5.3 mg). In addition, we confirmed that atrophic changes were less on pathological findings in the adrenal glands of MIF-treated rats. These results suggest that preoperative mifepristone administration may improve the residual adrenal function for CS. Our group is currently conducting experiments to investigate the levels of mRNAs for CYP11B1 in adrenal glands as assessment of the recovery of adrenal function.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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