Endocrine Abstracts

Objectives: BPH is characterised by prostate inflammation, which frequently occurs in men with metabolic syndrome (MetS). MetS is often associated with low testosterone (T). Recent evidence shows that low, rather than high, T is associated with BPH/lower urinary tract symptoms (LUTS). To evaluate if T replacement therapy (TRT) for 6 months in BPH men with MetS and low T, is able to improve LUTS and prostate inflammation.Methods: 120 men in waiting list f...

Background: Testosterone therapy in transgender men (TM) is aimed at achieving serum testosterone levels in the male reference range. It remains unknown if serum oestradiol levels in TM should be evaluated and/or adjusted. Although reported serum oestradiol levels in TM are variable in the current literature, these values may be affected through two possible mechanisms: serum oestradiol levels may increase through aromatization of exogenous testosterone, while the effects of e...

Bone morphogenetic proteins (BMPs) exhibit broad spectrum of biological activities in various tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung. BMPs are members of the transforming growth factor-β (TGF-β) family that bind to type II and type I serine-threonine kinase receptors, and transduce signals through Smad and non-Smad signalling pathways. BMPs together with other intraovarian growth factors are intimately involved in re...

Background: Polycystic ovary syndrome (PCOS) could be associated with increased risk of thyroid disorders. Possible associations between TSH and cardio-metabolic risk in PCOS are debated.Methods: National Register-based study on women with PCOS in Denmark. 18,476 women had a diagnosis of PCOS in the Danish National Patient Register. PCOS Odense University Hospital (OUH, N=1,146) was an embedded cohort including premenopausal women with PCOS and ...

Background: Studies have shown that the overall risk of cancer is not increased in Turner syndrome (TS). However, the pattern of cancer occurrence may be different than in the background population.Aim: To describe the cancer morbidity pattern in TS.Design: Nationwide epidemiological study using Danish registries on morbidity.Methods: 1,156 Females with TS diagnosed during 1960–2014 were identified using...