Endocrine Abstracts

Autoimmune diseases tend to coexist in the same subjects and are more often present in women than in men. Finland has the highest incidence of type 1 diabetes (TID). However, the coexistence of autoimmune diseases and excess risk compared to individuals without T1D in unknown. This study compares the proportion of autoimmune hypothyreosis and hyperthyreosis, Addison’s disease and celiac disease in adults in Finland with and without T1D. The study included 4,758 patients w...

Background: Bariatric surgery can profoundly ameliorate hyperglycemia and improve insulin sensitivity thus contribute to diabetes remission. However the detailed mechanisms underlying this effect is yet to be revealed. The aim of this research is to investigate the metabolic alterations in skeletal muscle after bariatric surgery and explore the possible mechanisms to further explain the diabetes remission effect of bariatric surgery.Methods: Duodenal-jej...

Background: There is a pressing need to develop a new and an effective strategy for early detection of T1D and to precisely distinguish T1D from type 2 diabetes (T2D). The aim of the present study was to find out the potential link between the erythrocytes carbonic anhydrase (CA) activity and 18O-isotopic exchange of breath CO2 in T1D and T2D.Methods: Fasting and post-dose breath and blood samples were collected simultaneously after...

Background: Sodium glucose co-transporter 2 inhibitors reduce the incidence of cardiovascular events in patients with type 2 diabetes mellitus based on the results of recent cardiovascular outcome studies. Herein, we investigated the effects of long-term treatment with empagliflozin on biochemical and immunohistochemical markers related to atherosclerosis development in apolipoprotein E knockout [Apo-E(−/−)] mice.Methods: At the ag...

The enzyme 5β-reductase (AKR1D1) catalyses an essential step in bile acid synthesis, but in addition, controls intra-cellular steroid hormone availability by generating 5β-reduced dihydrosteroid metabolites. As disturbances in steroid hormone and bile acid metabolism have potent effects on metabolic health and lipid homeostasis, we hypothesize that AKR1D1 may play a role hepatic lipid accumulation and contribute to the development of metabolic disease. We generated a...