ECE2019 Guided Posters Gestational and Type 1 Diabetes (11 abstracts)
Association between sleep disturbances and fear of hypoglycemia in adults with type 1 diabetes, data from VARDIA Study
Valentine Suteau 1, , Pierre-Jean Saulnier 3, , Matthieu Wargny 5 , Elise Gand 3 , Lucy Chaillous 5 , Séverine Dubois 2 , Ingrid Allix 2 , Fabrice Bonnet 6 , Anne-Marie Leguerrier 6 , Gérard Fradet 7 , Isabelle Delcourt Crespin 7 , Véronique Kerlan 8 , Didier Gouet 9 , Caroline Perlemoine 10 , Pierre-Henri Ducluzeau 11 , Matthieu Pichelin 5 , Linda Gonder-Frederic 12 , Stéphanie Ragot 4 , Samy Hadjhadj 5 , Bertrand Cariou 5 & Claire Briet 1,
1Institut MITOVASC, UMR CNRS 6015, INSERM 1083, Université d’Angers, Angers, France; 2Diabetes Department, CHU d’Angers, Angers, France; 3University of Poitiers, INSERM Clinical Investigation Center CIC1402, Poitiers, France; 4CHU Poitiers, Diabetes Department, Poitiers, France; 5L’institut du thorax, CHU Nantes, INSERM CIC1413, Nantes, France; 6CHU Rennes, Diabetes Department, Rennes, France; 7CH La Roche sur Yon, La Roche sur Yon, France; 8CHU Brest, Diabetes Department, Brest, France; 9CH La Rochelle, Diabetes Department, La Rochelle, France; 10CH Lorient, Diabetes Departme, Lorient, France; 11Diabetes Department, Tours, France; 12University of Virginia, Charlotteville, USA.
Aims: To assess the relationship between sleep quality and fear of hypoglycemia, glycemic variability and other diabetes-related outcomes in type 1 diabetes.
Methods: Our data were provided by the VARDIA Study, a multicentric observational cross-sectional study conducted between June and December 2015. Sleep characteristics were assessed by Pittsburgh Sleep Quality Index (PQ1I). Fear of hypoglycemia was measured with the Hypoglycemia Fear Survey version II (HFS-II). Glycemic variability was determined using the CV of three 7-points self-monitoring blood glucose profiles and the mean amplitude of glycemic excursion (MAGE). Comparisons between ‘good’ (PQ1I≤5) and ‘poor’ (PQ1I>5) sleepers and correlation between PQ1I and these different parameters were tested.
Results: 315 patients were eligible for PQ1I questionnaire analysis: 54% women, mean age 47±15 years old, mean diabetes duration of 24±13 years, HbA1c of 7.6±0.9% (60±7.5 mmol/mol). Average PQ1I score was 6.0±3.3 and 59.8% of the patients had a total PQ1I score >5. HFS-II score was significantly higher among patients with sleep disturbances (P<0.0001) and global PQ1I score was positively correlated with HFS-II (β=0.19; 95% CI=0.07;0.30). GV evaluated by CV or MAGE did not differ between ‘poor’ and ‘good’ sleepers (P=0.28 and 0.54, respectively).
Conclusions: Adult patients with type 1 diabetes have disturbed sleep quality which correlate with fear of hypoglycemia. This study suggests that fear of hypoglycemia is a target for intervention to improve sleep quality in adults with type 1 diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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