Endocrine Abstracts

Introduction: Klinefelter syndrome (KS) is the most common congenital abnormality causing primary hypogonadism. KS has a tendency for hypercoagulability.Case report: A 48 year old man diagnosed as having KS during the sterility test was admitted to our hospital emergency department after suffering a syncopal episode at work. He complained of difficulty breathing during the last two weeks and he was receiving bronchodilator therapy. He had suffered deep v...

Introduction: Klinefelter syndrome (KS) is the most common genetic form of male hypogonadism, despite becoming evident only after puberty. The syndrome is characterized by a primary gonadal defect, which results in small testes due to hyalinization of the seminiferous tubules, low to low normal range of serum testosterone levels and elevated serum gonadotrophins. Paradoxically, a few cases have been described, presenting with hypogonadotropism.Case-repor...

Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that predominantly affects women. The coexisting Klinefelter’s syndrome (47,XXY) and SLE was rare.Observations: We report a case of a middle-aged male had SLE discovered by arthralgia. He presented hypogonadism. Hormonal examinations showed a low serum testosterone level (0.3 ng/ml), and high follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels (24.1 ...

Introduction: Klinefelter syndrome (KS) represents the most common cause of hypergonadotrophic hypogonadism, with an estimated prevalence of 1:500 to 1:1000 men. This syndrome is characterized by the presence of an additional X chromosome. Eighty percent present with a 47,XXY karyotype and the remaining 20% present with a 47,XXY/46,XY mosaic or with multiple X chromosome aneuploidies, often with additional Y chromosomes. The presence of a 47,XXY/46,XX mosaic with male phenotyp...

Objective: To study the quality of life in women of reproductive age with different phenotypes of polycystic ovarian syndrome (PCOS).Materials and methods: 68 women with diagnosed polycystic ovarian syndrome aged 18–44 and 30 practically healthy women of the comparable age. According to the patient’s phenotype the main group was divided into 2 subgroups: patients with PCOS and obesity of varying severity (BMI> 25 kg/m2) and patie...

We are the first who studied the control and the role of transcription factors in the regulation of reproductive functions. Our presentation represents a short review of original data concerning external (temperature, calories restriction) and internal (hormones, protein kinases, RNA interference) in control of selected transcription factors (p53, NFkB, STAT1, CREB1), as well as their role in control of basic ovarian cell functions (proliferation, apoptosis, secretory activity...

Background: Obesity is significantly associated to several reproductive disorders in women. However, the molecular mechanisms involved in this association are complex and still not completely understood. The aim of our study was to determine the prevalence of reproductive disturbances in a group of women with morbid obesity.Methods: We conducted a cross sectional study in 50 women with a body mass index (BMI) ≥40 kg/m2 collected in the e...

Introduction: Hirsutism is the presence of excess hair growth in females as a result of increased androgen production and/or increased skin sensitivity to androgens. In a postmenopausal female presenting with hirsutism, a high level of clinical suspicion, a detailed history and physical examination, substantiated by focused biochemical and morphological confirmation is necessary.History: The authors present a case of a female with a longstanding history ...

Background: Obesity is an increasingly common health problem which has been found to affect female reproductive function in several aspects. The aim of our study was to determine the ovarian ultrasound features in women with morbid obesity.Methods: We performed a cross sectional study in 50 women with a body mass index (BMI) ≥40 kg /m2 collected over a period of 6 months (October 2017–March 2018). For each woman, a sus-pubic ultraso...

Secondary amenorrhea is defined as the cessation of regular menses for three months or the cessation of irregular menses for six months (1). Most cases of secondary amenorrhea can be attributed to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, or primary ovarian insufficiency the aim of this study to analyze the clinical, biological, etiological profile of secondary amenorrhea (2).Patients and methods: We conducted a retrospectiv...

Introduction: The disturbance of the lipid balance during pregnancy is common. Nevertheless, major hypertriglyceridemia during pregnancy is rare and can not be attributed to pregnancy.Methods: We report the case of a pregnant woman hospitalized at the national nutrition institute of Tunis (departement A) for the management of a major hypertriglyceridemia.Results: This is a 28-year-old female patient with ovarian stimulation-induced...

Background: In clinical practice, hirsutism is commonly seen among women of fertile age and defined as the presence of terminal hair with male distribution in women.Objective: The aim of the study was to assess the clinical, biochemical and etiologic features of hirsutism in women from the oriental region of Morocco.Materials and methods: 36 female patients presenting with hirsutism at Department of Endocrinology, Mohammed VI Hospi...

Introduction: Primary amenorrhea is an uncommon presentation in reproductive medicine requiring rigorous investigation. Primary amenorrhea is defined by the absence of menstrual cycle in girls after the age of 15 years, with or without the development of secondary sexual characteristics. The objective of the study is to determine the clinical, biological, etiological and therapeutic profile of primary amenorrhea in the Endocrinology-Diabetology department of Mohammed VI Univer...

Introduction: Turner syndrome is a chromosomal abnormality that affects phenotypic females who have one intact X chromosome and complete or partial absence of the second sex chromosome. In this genetic disease, the karyotype ranges from complet 45, X to forms of mosaicism in which a normal cell line (46, XX or 46, XY) or a second (or third) abnormal cell line is found. Mosaic turner syndrome (MTS) has a heterogeneous clinical presentation as well as a varied presence of malfor...