ECE2019 ePoster Presentations Pituitary and Neuroendocrinology (37 abstracts)
Thyrotropin-producing pituitary adenoma: 3 case reports
Faten Hadjkacem 1 , Imen Gargouri 1 , Dhouha Bensalah 1 , Manel Neifar 2 , Khouloud Boujelben 1 , Nadia Charfi 1 , Nabila Rekik 1 & Mohamed Abid 1
1Endocrinology Department, Sfax, Tunisia; 2Department of Clinical Chemistry, Sfax, Tunisia.
Introduction: Thyrotropin-secreting pituitary adenomas represent less than 1% of all pituitary adenomas. Usually, patients present mild or moderate signs of hyperthyroidism and Hormonal evaluation shows increased free thyroid hormone concentration with detectable, normal or increased serum thyrotropin (TSH) level. Herein we report three cases of thyrotropin adenomas with particular clinical and biological features.
Observations: Three patients, aged 25 38 and 75 years old, presented severe headaches with Visual acuity disturbance. Only one patient presented clinical features of hyperthyroidism such as tachycardia, tremor and weight loss without goiter. However in all the cases, biological assessment showed normal TSH serum level (1.41 to 3 μU/ml), with low or normal free thyroxine (FT4) (5.9 to 12 pmol/l). Two patients had hypopituitarism including corticotropic and gonadotropic axis associated with hypothyroidism in one case. Huge macro adenomas were diagnosed with CT scan and MRI with cavernous sinus invasion and compression of optic chiasma in one case. A transphenoidal surgery was performed in emergency in two cases of apoplexy and in one case because of the visual impairment. After histopathological examination two tumors stained for TSH alone, and one tumor stained for TSH and prolactin. During follow up, hypopituitarism remained under hormonal replacement and a transient diabetes insipidus after surgery. And two patients had tumor recurrence requiring radiotherapy.
Conclusion: Transphenoidal surgery remains the treatment of choice in patients with TSH-secreting pituitary adenomas and somatostatin analogs seem to be an alternative medical treatment to surgery in patients with recurrent macroadenomas or invasive tumors.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more