Endocrine Abstracts

Introduction: Patients with hyperparathyroidism have impaired carbohydrate metabolism characterized by insulin resistance, hyperinsulinemia and glucose intolerance. The objective of our work was to evaluate the prevalence of different carbohydrate metabolism disorders in patients with hyperparathyroidism and the impact of parathyroidectomy in improving glycemic counts.

Methods: Retrospective study conducted at the Department of Endocrinology Diabetology and Metabolic Diseases of the University Hospital of Casablanca for a period of 4 years (2014–2018) including all patients followed up for primary hyperparathyroidism.

Results: 25 patients were followed during this period for hyperparathyroidism. The average age was 56.7 years (34–76) with a clear female predominance (84%). The reason for consultation found was hypercalcemia in 84%. The main etiology of hyperparathyroidism was represented by a parathyroid adenoma in 95% of cases. Among these 25 patients, 5 had a disorder of glycoregulation including type 2 diabetes or a prevalence of 20%. Two out of five diabetic patients were operated on, following the removal of the parathyroid adenoma, we noted a significant improvement of the postoperative glycemic figures and also compared to the control group of the 3 non-operated diabetic patients.

Conclusion: During hyperparathyroidism, carbohydrate homeostasis may break down, leading to abnormal carbohydrate metabolism, the main finding of which in our work was type 2 diabetes. Our work highlights the importance of systematically detecting glycoregulation disorders, particularly diabetes in affected patients.