Endocrine Abstracts

Background: Vascular adhesion protein-1 (VAP-1) is a novel driver of tissue inflammation and fibrosis and may contribute to fibrotic complications of neuroendocrine tumours (NETs). We studied the VAP-1 expression in midgut NETs, which are associated with desmoplasia, and carcinoid heart disease (CHD), a significant complication of metastatic midgut NETs.Methods: Immunohistochemical analysis of paraffin-embedded midgut NETs and CHD valves were stained for...

Background: PRRT, licensed for gastroenteropancreatic (GEP) NETs, has been used with somatostatin analogues such as lanreotide autogel (LAN). PRELUDE is the first international, multicentre retrospective study, with central radiology reading, to describe use of LAN with PRRT (LAN-PRRT) in advanced NETs.Methods: PRELUDE (NCT02788578) was an international, retrospective, non-comparative analysis of medical records of patients receiving LAN with 177Lu-DOTAT...

Neuroendocrine tumours (NETs) of unknown primary (UP-NETs) represent up to 22% of NETs. Primary site identification enables patients to access appropriate treatment but is not always possible by immunohistochemistry or imaging. Given the epigenetic dysregulation of NETs, we aimed to use methylation array data to determine UP-NET tissue-of-origin. DNA from formalin-fixed paraffin embedded tissue from 76 pancreatic NET (PanNETs) (54 training and 22 validation samples) and 53 sma...