SFEBES2018 Poster Presentations Reproduction (23 abstracts)
Reproductive Life Course Project: Preliminary data from UK Turner Syndrome Pregnancy audit
Elizabeth Burt 1 , Antoinette Cameron Pimblett 1 , Mollie Donohoe 2 , Matilde Calanchini 3 , Claire Morton 2 , Arlene Smyth 4 , Antoinia Brooke 2 , Helena Gleeson 5 , Helen Simpson 6 , Helen E Turner 3 , Melanie C Davies 6 & Gerard S Conway 1
1University College London, London, UK; 2Royal Devon & Exeter, Exeter, UK; 3Oxford University Hospital, Oxford, UK; 4Turner Syndrome Support Society, Glasgow, UK; 5Birmingham University Hospitals, Birmingham, UK; 6University College London Hospital, London, UK.
Turner Syndrome (TS) affects 1:2500 females and is caused by the partial or complete loss of one X chromosome. About 80% of women with TS experience primary amenorrhea and therefore the only option for fertility treatment is ovum donation (OD). The remaining 20% may have the opportunity for a spontaneous pregnancy. Pregnancy in women with TS has been associated with excess obstetric risk such as miscarriage and hypertension. Maternal mortality has been estimated to be 2% risk of TS mainly due to the risk of aortic dissection. To date there has been no data to document UK pregnancy data in TS. Here we present preliminary data from the Reproductive Life Course Project (RLCP) that aims to conduct a UK- wide TS pregnancy audit to document pregnancy outcomes in TS.
Methods: Women with TS who had achieved pregnancy were identified by collaborating centres and the TS Support Society (TSSS). Telephone interviews were conducted to collect data regarding; mode of conception, mode of delivery and TS-specific complication such as cardiac events and hypertension. Currently 7 centres are recruiting of which 3 have completed data collection. The TSSS subjects self- reported to UCLH.
Results: Seventy one women with TS have reported 110 pregnancies of which 39% were spontaneous conceptions and 61% were achieved with ovum donation (OD). Miscarriage rates were 35% for spontaneous conceptions and 26% for OD conceptions. No case of acute cardiovascular morbidity such as aortic dissection has so far been identified.
Conclusions: The RLCP is on target to make a major contribution to the world data on pregnancy safety for women with TS. Initial results show an expected high miscarriage rate and stratification of obstetric risks is underway. The project is actively recruiting centres for wider collaboration. For further information see www.RCLP.uk
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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