SFEBES2018 APPLIED PHYSIOLOGY WORKSHOP Metabolites as hormones (3 abstracts)
Imperial College London, London, UK.
Prospective studies and clinical trials have repeatedly demonstrated that high intake of dietary fibre reduces the incidence of metabolic diseases and their risk factors. An increased intake of dietary fibre raises the amount of undigested material available for fermentation by the gut microbiota and the production of short chain fatty acids (SCFA). SCFA have been shown to regulate energy homeostasis through various metabolic pathways and receptor-mediated mechanisms. The majority of the available evidence to support a role of SCFA in metabolic regulation has been obtained from animal models. The presentation will provide an overview of translational human research that has investigated the impact of SCFA on hormone release at different organ sites.