Endocrine Abstracts

According to population registries prevalence of chronic kidney disease (CKD) in the world is about 10%. Global trends show growth of CKD due to diabetic nephropathy, chronic tubulointerstitial nephritis, secondary nephropathies. Kidney transplantation is a ‘golden standard’ in CKD treatment. Is it performed about 100 times per year in The republican research and practice center for organ and tissue transplantation. The aim of the study was to evaluate menstrual function and describe aspects of endocrine status in women with transplanted kidney. The study included 55 women aged 18–44 (mean age 31±3.8) who had undergone kidney transplantation within last 5 years. They had adequate graft function and were administered immunosuppressive drugs. Control group consisted of healthy regularly menstruation women matched by age. 68% of women with kidney transplantation have regular menstruations with confirmed ovulation, 15% show oligomenorrhea, 17% are amenorrheic. Menstrual function restoring occur within one year after kidney transplantation. Luteinizing and follicle stimulating hormones (on 5th and 25th days) were similar in two groups. Oligomenorrhea was accompanied by significant decrease in progesterone level to 5.48 pmol/L (21 day), statistically significant (P<0.01) increase in estradiol level (up to 2.5 nmol/L) in the follicular phase. Elevated prolactin level to 948 mME/L (P<0.01) and significant decrease of testosterone level to 0.1 pg/mL (P<0.01) were found in 33% of kidney transplanted women. Women included in the study group who had normal menstruations demonstrated Antimullerian hormone levels significantly (P<0.01) lower (1.30–2.45 ng/mL) than in oligo- or amenorrhea. Vitamin D concentrations were comparable. Further studying of menstruation, ovulation and hormone functioning in patients who had undergone kidney transplantation is an actual topic, which aims to preserve reproductive potential and improve quality of life of women, giving them an opportunity to conceive and give birth to healthy children.