Endocrine Abstracts

Aim: Assess the effectiveness of management of pregnant women with type 1 diabetes mellitus (DM 1) with continuous subcutaneous insulin infusion (CSII).

Materials and Methods: Pregnant women with DM 1 with CSII (n=21) - the main group and on multiple daily insulin injections (MDI) (n=216) - the comparison group. We used different models of the Medtronic pumps. The inclusion in the comparison group carried out by a continuous method. The term of delivery, the frequency of preeclampsia, the level of glycated hemoglobin (HbA1c) in the 3rd trimester were used as efficiency criteria.

Results: In the main group, premature delivery was only 9.5%, compared with 53.7% in the group of MDI. The incidence of preeclampsia in the main group was significantly lower and amounted to 19.1%, compared with 52.8% in the comparison group. Also, the level of HbA1c in the third trimester in the main group were significantly less than in the comparison group and amounted to 5.92%, in comparison with 6.73%.

Conclusions: The continuous subcutaneous insulin infusion is an effective method of management of pregnant women with type 1 diabetes, which allows obtaining a full-term child in 90% of cases against the background of the optimal state of carbohydrate metabolism, reducing the frequency of preeclampsia.