Endocrine Abstracts

Objective: To study the metabolic profile of patients after surgery for pituitary tumors.

Methods: This retrospective study included 1138 patients from 2000 to 2017. Those with prolactinomas, pituitary apoplexy and surgery elsewhere were excluded. The analysis included 525 patients, non-functional tumors (143), acromegaly (267), Cushing’s disease (113) and TSHoma (1). The patients’ blood pressure, blood sugar, lipid profile and body mass index (BMI) was serially followed up. The median duration of follow up was 2.6 years (range 1–14 years). The follow up included nonfunctional tumors (71) and patients in remission acromegaly (106), Cushing’s disease (70) and TSHomas (1).

Results: At diagnosis 51, 68 & 79% of patients respectively with non-functional tumors, acromegaly & Cushing’s disease had either prediabetes or diabetes (51% vs 68%, P <0.001 & 51% vs79%, P <0.001) Hypertension was present in 29, 28 & 64% of patients respectively with non-functional tumors, acromegaly and Cushing’s disease (29% vs 64%, P<0.001). Hypercholesterolemia was present in 48, 32 & 65% of patients respectively with non-functional tumors, acromegaly and Cushing’s disease (48% vs 65%, P<0.01). The median BMI was 24.8, 26.1 & 29.3 kgs/M² in patients respectively with non-functional tumors, acromegaly & Cushing’s disease (24.8 vs 29.3, P<0.41). At follow-up, prediabetes & diabetes resolved in 24, 43 & 50% of patients with non-functional tumors, acromegaly & Cushing’s disease (24% vs 43%, P<0.01 & 24% vs 50%, P<0.001). Hypertension resolved in 27, 19 & 65% of patients respectively with non-functional tumors, acromegaly & Cushing’s disease (27% vs 65%, P<0.001). The BMI in patients with acromegaly increased from 26.1 to 28 kgs/M² (P<0.70).

Conclusions: At follow up, diabetes & hypertension resolved respectively in 50% & 65% of patients with Cushing’s disease. Diabetes & hypertension resolved respectively in 43% & 19% of patients with acromegaly. Obesity and dyslipidemia persisted in all the sub-groups.