SFEBES2018 Poster Presentations Diabetes & cardiovascular (27 abstracts)
Patients with diabetes are at no greater risk for contrast induced nephropathy than those without diabetes?
Jeffrey D Zajac 1, , Thinn Thinn Khine 1, , Niloufar Torkamani 1, , Leonid Churilov 3 , Mariam Hachem 2 , Raymond J Robbins 4 , Karen Tan 2 , Richard J MacIsaac 5 , Simone L Patterson 1 , Natalie Yang 2, , Ruth P Lim 2, & Elif I Ekinci 1,
1Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia; 2Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia; 3The Florey Institute of Neuroscience & Mental Health, Melbourne, Victoria, Australia; 4Department of Administrative Informatics, Austin Health, Heidelberg, Victoria, Australia; 5Department of Endocrinology and Diabetes, St Vincent’s Hospital Melbourne, Melbourne, Victoria, Australia; 6Department of Radiology, Austin Health, Heidelberg, Victoria, Australia.
Introduction: Contrast-induced nephropathy (CIN) is an important cause of acute kidney injury (AKI) in inpatients. However, the prevalence and predisposing factors for CIN remain poorly documented. The aim of this study was to investigate the association between CIN, kidney function and diabetic status in inpatients.
Methods: We identified inpatients who received IV contrast prior to a computed tomography (CT) scan between July 2012 to March 2018 at Austin Health, Melbourne. Our study was restricted to patients > 54 years as all patients above this age who have a HbA1c measurement when admitted to our hospital as part of the Diabetes Discovery Initiative. Outpatients, patients <54 years, patients who had multiple CT scans with IV contrast and patients with a baseline estimated Glomerular Filtration Rate (eGFR) <30 ml/min per 1.73 m2 were excluded. We obtained creatinine measurements at baseline and 48 hours post contrast administration and defined CIN as an absolute rise in creatinine of ≥44 mmol/l. Patients were divided into those with and without a history of diabetes and/or those with renal impairment (defined as an eGFR < or ≥60/ml/min per 1.73 m2). Firth logistic regression model was used for data analysis.
Results: Out of 1280 patients, 28.75% had a history of diabetes and 29.53% had baseline eGFR of <60/ml/min per 1.73 m2 and 70.47% has baseline eGR of ≥60/ml/min per 1.73 m2. The overall prevalence of CIN was 3.2%. Pre-existing diabetes, degree of glycaemic control (assessed by admission HbA1c) or presence of renal impairment was not associated with an in increased risk of developing CIN.
Conclusion: Patients with or without diabetes who had a CT scan with IV contrast had a similar risk for the development of CIN after adjusting for other variables. It is possible a larger data set may yield different outcomes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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