Endocrine Abstracts

NOTICE OF RETRACTION: This abstract is retracted at the request of the author.

This study aimed to re-audit the surgical and medical treatment of acromegalic patients in the Sussex Pituitary Multidisciplinary Team (MDT). This involved assessing biochemical control and treatment complication rates. The study compared treatment outcomes with previous 2010 audits and national published standards. Fourty patients (25 males, aged between 23 and 79 years at diagnosis) were identified from East Sussex as being treated for acromegaly between 2010 and 2016. Data collection involved accessing patients’ notes and hospital electronic information systems; this included diagnosis date, symptoms, Growth Hormone (GH) and Insulin Growth Factor-1 (IGF-1) values, imaging and surgical, medical and radiotherapy outcomes. Data was recorded on the UK Acromegaly Register proforma and analysed using Excel 2016. Macroadenomas were more common than microadenomas (32 vs 7 respectively). Surgery was first-line treatment for 75% of patients and at least 3 months’ post-surgery, 48.6% (n=18) were biochemically controlled. The surgical success rate for obtaining full biochemical control (both normal GH and IGF-1) for microadenomas, intrasellar and extrasellar macroadenomas were 60, 41.7 and 15% respectively. For medically treated patients, 36.4% (n=8) were biochemically controlled with Somatostatin analogues contributing to 50% of this. 60% (n=6) of radiotherapy patients were biochemically controlled at some point with 3 patients achieving this without concurrent medication. In conclusion, current clinical practice adheres to 2014 guidelines. There was an improvement in full biochemical surgical success rates from previous 2010 audits by 500% for extrasellar macroadenomas. Medical and radiotherapy outcomes were similar to 2010 audits. Nonetheless improvement areas were identified which includes regular post-op biochemical tests. Results were given to the Sussex Pituitary MDT to improve service provision and the national acromegaly database.