Endocrine Abstracts

Introduction: Adults with Type 1 Diabetes Mellitus (T1DM) are at risk of premature osteoporosis and fractures. The onset of T1DM typically starts during childhood and adolescence thus the effects of diabetes on the skeleton may be established in this period. Studies in children primarily use DXA to evaluate the effects of T1DM on bone with conflicting results. We present the first study in children assessing the impact of T1DM on skeletal microstructure and strength, using HRp...

Background: X-rays of the hand and wrist are routinely performed to evaluate bone age (BA) in children with endocrine and growth disorders. BA is used essentially to assess growth potential, but the BA x-ray can reveal additional morphological abnormalities. Incidental findings on the BA x-ray can aid clinical diagnosis and prompt appropriate further investigations to establish the child’s final diagnosis.Methods: A 10-year retrospective review of 1...

Introduction: Denosumab, a human monoclonal antibody that inhibits activation of osteoclasts provides sustained suppression of bone turnover in osteolytic bone disease. Denosumab has rarely been associated with late hypercalcaemia following therapeutic administration for bone tumours in children, bone metastases in adults and in children with Osteogenesis Imperfecta Type VI.Case report: A male child of Indian origin was referred for advice to GOSH from a...

Background: Osteoporosis and increased fracture risk associated with cystic fibrosis (CF) are becoming more relevant with improved life expectancy in this disease. The evolution of CF-related bone disease remains unclear.Aims: To evaluate change in bone mineral density (BMD) in individuals with CF from age 10 to 30 y.Methods: Data from the UK CF Trust registry, which contains anonymised clinical information, was used to evaluate BM...

Introduction: Autosomal dominant hypocalcaemia (ADH) is caused by activating mutations of the calcium sensing receptor (CaSR). Symptomatology ranges from asymptomatic hypocalcaemia to paraesthesia, tetani, laringospasm and, seizures. This is the first report of congenital hyperinsulinism (CHI) in a child with ADH.Case report: A female infant, born at term from non-consanguineous parents, presented on D2 with persistent asymptomatic hypoglycaemia requirin...

Introduction: Hypocalcemia is a well known adverse reaction of phosphate supplements but rarely reported. We report a case of Infant presenting with hypocalcemic seizures after initiation of phosphate supplements.Clinical case: A baby Girl was born at 34+4 weeks gestation. She was admitted in NNU for preterm care. The admission was complicated by severe Gastroesophageal reflux disease(confirmed by PH impedance study), anemia and sepsis. She was discharge...