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Belgian Endocrine Society 2018

BES 2018

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review of the literature

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ea0057012 | Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review of the literature | BES2018

Immune checkpoint inhibitors and type 1 diabetes mellitus: a case report and systematic review of the literature

de Filette Jeroen MK , Joeri Pen , Brigitte Velkeniers , Kharagjitsingh Aan V

Introduction: Immune checkpoint inhibitors have revolutionized the treatment of advanced malignancies. These monoclonal antibodies target cytotoxic T-lymphocyte antigen-4 (CTLA-4), programmed cell death 1 (PD-1) or its ligand (PD-L1). Endocrine side effects are common, and while hypophysitis and thyroid disorders are predominant, checkpoint-blockade associated diabetes mellitus deserves further notice.Methods: We present the case of a 61-year old male wi...
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Endocrine Abstracts
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