ea0057019 | Adrenocortical function during prolonged critical illness and beyond: a prospective observational study | BES2018
Bram Peeters
, Philippe Meersseman
, Sarah Vander Perre
, Pieter J Wouters
, Dimitri Vanmarcke
, Yves Debaveye
, Jaak Billen
, Pieter Vermeersch
, Lies Langouche
, Greet Van den Berghe
Aim of the work: The time courses of ACTH, (free) cortisol and cortisol metabolites beyond the first week of critical illness and upon recovery have not been documented. We studied adrenocortical function over time in relation to critical illness duration and presence of sepsis/septic shock, to initiation of glucocorticoid treatment, and to recovery/death.Methods: Patients still in ICU on day 7 (N=392) and 20 matched healthy subjects were includ...