ECE2018 Symposia The role of sperm epigenome in fertility and inheritance (3 abstracts)
Greece.
Our lifestyle habits and environmental exposures are typically considered to affect only our health (with the exception of pregnant mothers). Nevertheless, there is epidemiological evidence from human studies that adverse health consequences can also be observed in offspring and grand offspring (e.g. Roseboom et al., Molecular and Cellular Endocrinology, 2001). The mechanisms of trans- or inter-generational epigenetic inheritance are currently not known. We, and others, have therefore turned to animal models to try to understand the mechanisms involved. During my talk I will present two animals models of inter- or trans-generational epigenetic inheritance and what we have learnt from them about how information is transmitted through the germline (Ost et al., Cell, 2014; Klosin et al, Science 2017).
References
1. Klosin A., Casas E., Hidalgo-Carcedo C., Vavouri T., Lehner B., Transgenerational transmission of environmental information in C. elegans, Science. 2017 April 21;356(6335):320323. doi: 10.1126/science.aah6412.
2. Öst A., Lempradl A., Casas E., Weigert M., Tiko T., Deniz M., Pantano L., Boenisch U., Itskov P.M., Stoeckius M., Ruf M., Rajewsky N., Reuter G., Iovino N., Ribeiro C., Alenius M., Heyne S., Vavouri T., Pospisilik J.A. Paternal diet defines offspring chromatin state and intergenerational obesity. Cell. 2014 December 4;159(6):135264. doi: 10.1016/j.cell.2014.11.005.