ECE2018 Poster Presentations: Adrenal and Neuroendocrine Tumours Clinical case reports - Pituitary/Adrenal (21 abstracts)
From gastric sleeve to diagnosis of a rare familial multiple endocrine neoplasia type 1
Anca Georgiana Tudurean-Olteanu 1 , Radu Danilă 2, , Mirela Claudia Nechita 1 , Andreea-Nicoleta Dumitrascu 1 , Cristina Preda 1, , Letiţia Leuştean 1, , Anamaria Hrişcă 1, & Maria Christina Ungureanu 1,
1Endocrinology Department, ‘Saint Spiridon’ Clinical Emergency Hospital, Iasi, Romania; 2General Surgery Department, ‘Saint Spiridon’ Clinical Emergency Hospital, Iasi, Romania; 3‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi, Romania.
Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant hereditary disorder characterized by the presence of two of the three main endocrine tumors that are parathyroid, pituitary adenomas and enteropancreatic tumors.
Case-report: We report a case of a 71-year-old obese patient with repeated unsuccessful attempts to weight loss who was admitted to the surgical department for the bariatric treatment of obesity (BMI=48,22 kg/m2); the preoperatory evaluation discovered hyperparathyroidism and an adrenal adenoma. Evaluated in the laşi Endocrinological Department, was diagnosticated also with non-functional pituitary macroadenoma and anterior pituitary insufficiency, two non-functional neuroendocrine pancreatic tumors and Recklinghausen neurofibromatosis. He underwent minim invasive partial parathyroidectomy due to high calcium level with local anesthesia, but with recurrence of hyperparathyroidism after 6 months. He initially refused pituitary or pancreatic surgery, now is reconsidering pituitary surgery due to high anesthesic risk for the next subtotal parathyroidectomy. The pancreatic tumors was nonsecreting and no evolutive signs during 2 years. Family investigation revealed son with primary hyperparathyroidism (operated) and prolactinoma (Cabergoline), one daughter with primary hyperparathyroidism (operated) and pituitary prolactinoma (Cabergoline) and one daughter with hyperprolactinemia. The grandchildren were clinical investigated (no endocrine tumors) and genetical tested.
Conclusions: We reported a rare case of familial syndrome of Multiple Endocrine Neoplasia type 1 and simultaneous occurrence of bilateral adrenal adenomas and Recklinghausen neurofibromatosis in a patient clinically diagnosed as having MEN type 1.
Keywords: Multiple endocrine neoplasia 1, primary hyperparathyroidism, prolactinoma, Recklinghausen neurofibromatosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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