ECE2018 Poster Presentations: Reproductive Endocrinology Female Reproduction (48 abstracts)
Potential toxicity of cefuroxime therapy on rats’ ovary
Amal Tahri 1 , Manel Naifar 2 , Kamilia Kssouda 1 , Tarak Rebai 3 , Fatma Ayedi 2 , Mohamed Abid 4 & Zouheir Sahnoun 1
1Research Unit of Pharmacology and Toxicology of Xenobiotics
(UR12 ES13) and laboratory of pharmacology-Sfax Medicine School, Sfax, Tunisia; 2Biochemistry laboratory, Habib Bourguiba Hospital, Sfax, Tunisia; 3Research Unit of Pharmacology and Toxicology of Xenobiotics (UR12 ES13) and laboratory of histo-embryology, Sfax Medicine School, University of Sfax, Tunisia, Sfax, Tunisia; 4Endocrinology Department, Hedi Chaker Hospital, Sfax, Tunisia.
The aim of the present study was to evaluate the potential toxicity of Cefuroxime (CFR), a second-generation cephalosporin antibiotic, on ovary of ‘wistar’ rats. A total of 32 adult female rats (12 weeks old) were intraperitoneally injected with CFR at a dose of 0, 30, 60 or 120 mg/kg, divided into two equal doses daily, for 7 days and sacrificed 24 h after the last dose. Biochemical assays showed significant reduction in oestradiol and progesterone levels in comparison with the control group (P<0.05). In addition, ovarian levels of reduced glutathione (GSH) and glutathione peroxidase (GPx) activity were decreased in the CFR-treated groups in a dose dependent manner (P<0.05). However, ovarian malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) seemed not to be influenced by this drug. In consistance with these results, histological investigation showed that the structure of the ovary was perfectly conserved among CFR-treated rats. In conclusion, CFR induced oxidative stress and disrupt hormonal balance in the rats’ ovaries without disturbance of normal structure of ovaries.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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