Endocrine Abstracts

Background: Polycystic ovary syndrome (PCOS) occurs in women of reproductive age and is characterized by hyperandrogenism, polycystic ovaries, oligomenorrhea or amenorrhea. Estimated prevalence is at least 6.5%. Women having PCOS tend to be overweight or obese. In addition to endocrine, metabolic and gynecological, features of PCOS, a number of psychological problems add up which affect quality of life and psychological well-being in women with PCOS.

Materials and methods: Case-control study conducted from July 2017 to January 2018 at ABSTH Gujrat after ethical approval from IRB. Non-probability consecutive sampling was used. 50 patients having PCOS were included in study and compared to 50 healthy subjects after their consent. Clinical characteristics of PCOS were compared in both groups. Assessment of anxiety and depression was done using DSM-V criteria. Statistical analysis was done using SPSS 20.0.

Results: Mean age was 26.16+5.54 and 25.48+6.27 years, mean weight 72.26+16.53 and 64.7+13.51 kg and mean BMI was 28.96+5.87 and 24.55+5.24 kg/m² in cases and controls respectively. Hirsutism (72% vs 18%), oligomenorrhea or amenorrhea (98% vs 12%), hypertension (28% vs 6%), weight gain (50% vs 12%), heaviness of voice (12% vs 6%), enlargement of clitoris (16% vs 6%), hair fall (74% vs 34%), acne (68% vs 16%) and hyperglycemia (4% vs 0%) were compared in both groups. Presence of hirsutism, oligomenorrhea or amenorrhea, hypertension, weight gain, hair loss and acne were significantly associated with PCOS (P<0.05). BMI was independent risk factor for development of anxiety (P=0.001) and depression (P=0.000). Relative risk of anxiety in cases was 3.3333 (95% CI, 0.9751–11.3954) while that of depression was 5.1667 (95% CI, 2.3652–11.2863). Depression was significantly associated with PCOS (P<0.001) but anxiety was not significantly associated (P=0.055).

Conclusion: Depression is significantly present in patients with PCOS as compared to healthy women with BMI as independent risk factor.