Endocrine Abstracts

Polycystic Ovary Syndrome increases the risk of cardiovascular diseases. To factors predisposing to cardiovascular diseases belong: hypertension, lipid and carbohydrate profiles, smoking and reduced physical activity. The aim of this study was to determine the association between selected factors predisposing to cardiovascular diseases and anthropometric parameters and CRP concentration in women with Polycystic Ovary Syndrome. The study was conducted amongst 43 women, aged 18-39, diagnosed with Polycystic Ovary Syndrome based on the 2003 Rotterdam criteria. The patients were hospitalized in Endocrinology City Hospital in Piekary in 2016-2017. The selected factors predisposing to cardiovascular diseases (CVD) were: blood pressure different from 135/85mmHg, total cholesterol>200mg/dl, LDL>135mg/dl, HDL<50mg/dl, triglycerides>150mg/dl, HOMA-IR>1,5, glucose>100mg/dl, BMI>24,9, smoking and reduced or very reduced physical activity and assigned 1 point for every existed factor. Body composition was measured with TANITA BC-420 Analyzer. The results were used to signify the anthropometric indicators (BMI, BAI, VAI, WHR, WHtR). To establish the statistical relationship statistically significant value P≤0.05 was accepted also to verify the power of correlation between two chosen variables r-Pearsona coefficient was used. Selected factors predisposing to CVD have been recognized in 90.7% of examined women, including at least 4 factors in 22 women. Positive correlation was observed between BAI and predisposing CVD factors (P≤0.05, r=0.35), as well as between VAI and predisposing CVD factors (P≤0.05, r=0.26), WHR and predisposing CVD factors (P≤0.05, r=0.38), also WHtR and predisposing CVD factors (P≤0.05, r=0.46). Higher numbers of predisposing CVD factors is connected to higher CRP concentration (P≤0.05, r=0.22). The correlation between predisposing CVD factors and BMI (kg/m²) was observed (P≤0.05, r=0.45). Anthropometric parameters as well as CRP concentration are useful tool in determining the risk of cardiovascular diseases in women with Polycystic Ovary Syndrome.