Endocrine Abstracts

Polycystic ovary syndrome is associated with lipid and carbohydrate metabolism disorders, leading to obesity and insulin resistance. The aim of the study was to asses the correlation among anthropometric parameters, metabolic markers (lipid and carbohydrate profiles) and CRP as inflammatory indicator in women with Polycystic Ovary Syndrome. The study consists of 43 women diagnosed with Polycystic Ovary Syndrome based on 2003 Rotterdam criteria. The patients were hospitalized in Endocrinology City Hospital in Piekary in 2016-2017. In order to estimate the anthropometric parameters: BMI, BAI, VAI, WHR and WHtR were used. Concentration of total cholesterol (TC), LDL cholesterol, HDL cholesterol, triglycerides (TGC) also glucose, insulin, HOMA-IR, QUICKI index and CRP were taken from the patients’ medical records. CRP>5 was adopted as the anomalous value. Statistically significant value P≤0,05 was assumed. In the examined group the average BMI (kg/m²) was 28,0±6,9, BAI 32,7±6,4, VAI 1,7±0,8, WHR 0,8±0,1, WHtR 0,6±0,1. The average concentration of TC (mg/dl) was 184,2±40,2, LDL cholesterol (mg/dl) 99,2±34,9, HDL cholesterol (mg/dl) 64,8±20,6, TGC (mg/dl) 101,2±58,3. The carbohydrate profile consisted of average concentration of glucose (mg/dl) 91,2±13,2, insulin (uU/mL) 13,4±10,9, as well as average values of HOMA-IR index 0,3±0,0 and QUICKI index 3,3±1,0. The average concentration of CRP (mg/l) was 3,4±1,6. HDL cholesterol was statistically lower in patients with higher BMI (P≤0,05, r=0,40), BAI (P≤0,05 r=0,3), VAI (P≤0,05, r=0,54), WHR (P≤0,05, r=0,25) and WHtR (P≤ 0,05, r=0,38). TGC correlated positively (P≤0,05, r≥0,16) with BMI, BAI, VAI, WHR, WHtR. There were not significant correlation observed among TC, LDL cholesterol and studied variables. Fasting glucose and insulin correlated positively (P≤0,05, r≥0,23) with BMI, BAI, VAI, WHR and WHtR. Women with higher value of HOMA-IR index had statistically higher BMI (P≤0,05, r=0,45), BAI (P≤0,05, r=0,27), VAI (P≤0.05, r=0,46), WHR (P≤0,05, r=0,40) and WHtR (P≤0,05, r=0,46). There was negative correlation (P≤0,05, r≥0,33) between anthropometric parameters and the value of QUICKI index. Positive correlation (P≤0,05, r≥0,23) between CRP concentration and BMI, BAI, VAI, WHR and WHtR was observed in the examined group of women. Anthropometric parameters are functional indicators of carbohydrate and lipid metabolism disorders, (except TC and LDL cholesterol concentration) in PCO-S women. High BMI, BAI, VAI, WHR and WHtR might imply an inflammation in the examined group.