ECE2018 Poster Presentations: Reproductive Endocrinology Bone ' Osteoporosis (1 abstracts)
Bone mineral density in oligomenorrhoeic women with polycystic ovary syndrome
Dusan Ilic 1 , Ivana Bozic-Antic 1 , Tamara Bogavac 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic-Milutinovic 3 , Olivera Stanojlovic 4 , Bojana Popovic 1 , Tatjana Isailovic 1 , Valentina Elezovic-Kovacevic 1 , Sanja Ognjanovic 1 & Djuro Macut 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinial Center of Serbia, Belgrade, Serbia; 2CHC Bezanijska kosa, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Oligomenorrhoea have negative impact on bone mineral density (BMD). The aim of this study was to analyze BMD in oligomenorrhoeic women with polycystic ovary syndrome (PCOS), and healthy controls with regular menstrual cycles.
Methods: We analyzed 29 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 23.6±4.7 years, BMI: 24.9±6.1 kg/m2) and 22 healthy BMI-matched controls (HC) (age 31.6±6.3 years, BMI 24.9±6.1 kg/m2). In follicular phase of menstrual cycle we determined BMD by osteodensitometry, fasting serum glucose (FG), insulin, lipids, calcium, phosphate, albumin, PTH, testosterone, SHBG, DHEAS, 17OH-progesterone, androstenedione, estradiol, TSH, fT4, fT3. HOMA, FAI and corrected calcium were calculated. Differences between groups were age-adjusted.
Results: There was no difference between groups in BMD measurements on L1-L4, total and neck femur. PCOS had higher testosterone (2.4±0.8 vs. 1.4±0.5 nmol/l, P=0.002), androstenedione (3.2±1.1 vs. 1.9±0.4 ng/ml), corrected calcium (2.2±0.9 vs. 2.1±0.9 mmol, P=0.011). There were no between-groups differences in other measurements. PCOS women showed significant correlation between L1-L4 BMD and LH (r=0.49, P=0.04), L1-L4 BMD and DHEAS (r=−0.68, P=0.001), total femur BMD and TSH (r=−0.56, P=0.012), and total femur BMD and PTH (r=−0.65, P=0.022).
Conclusions: Oligomenorrhoeic women with PCOS did not differ in BMD to the BMI matched healthy controls.
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Endocrine Abstracts
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