ECE2018 Poster Presentations: Pituitary and Neuroendocrinology Pituitary - Clinical (101 abstracts)
Hypopituitarism in primary empty sella
Karin Zibar Tomšić 1 , Marin Deškin 2 , Ivana Kraljević 3 , Tina Dušek 3, , Mirsala Solak 3 , Tanja Škorić Polovina 3 , Annemarie Balaško 3 & Darko Kaštelan 3,
1Vuk Vrhovac University Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia; 2General Hospital Bjelovar, Bjelovar, Croatia; 3Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia; 4School of Medicine, University of Zagreb, Zagreb, Croatia.
Empty sella is characterized by the radiological appearance of an enlarged or deformed sella turcica which is completely or partially filled with cerebrospinal fluid resulting in a displacement of the normal pituitary gland. Primary empty sella (PES) refers to the empty sella appearance of unknown etiology, diagnosed after excluding a history of previous pituitary pathology. The prevalence of hypopituitarism in empty sella syndrome varies between 2 and 32% in different published series. The aim of this study was to investigate the incidence of hypopituitarism among PES patients. We conducted a retrospective analysis of the pituitary function in 46 consecutive patients (19 male, 27 female, median age 58 years (27–78)) with PES who were referred to the University Hospital Centre Zagreb between 2010 and 2016. Hypopituitarism was defined as the deficiency of one of the three hormonal axes (corticotroph, thyreotroph or gonadotroph). Hypopituitarism was present in 11 out of 46 PES patients (seven male, four female). Five patients had one pituitary axis insufficiency, four patients had two pituitary axis insufficiency and two patients had the insufficiency of all three pituitary axes. The insufficiency of the corticotroph, thyreotroph and gonadotroph axis was present in 17%, 17%, and 15% of patients, respectively. According to our results, every fourth patient with PES has at last one pituitary axis insufficiency. Therefore, in all PES patients regular endocrine work-up should be recommended.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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