ECE2018 Poster Presentations: Pituitary and Neuroendocrinology Pituitary - Clinical (101 abstracts)
Endocrine abnormalities in primary empty sella syndrome
Rym Belaid 1 , Nadia Mchirgui 1 , Imen Rojbi 1 , Ibtissem Ben Nacef 1 , Amel Jaidane 2 , Karima Khiari 1 , Haroun Ouertani 2 & Néjib Ben Abdallah 1
1Departement of Endocrinology, Internal Medicine A, Charles Nicolle’s Hospital, Tunis, Tunisia; 2Department of Endocrinology, Military Hospital, Tunis, Tunisia.
Background: The term primary empty sella (PES) makes reference to the herniation of the subarachnoid space within the sella turcica in patients with no history of pituitary tumor,surgery or radiotherapy. The aim of our study was to evaluate hormonal abnormalities associated with PES.
Methods: Thirty-six patients with PES were retrospectively analysed over a 24-year period [1992-2016].Patients were evaluated for pituitary function with basal hormone levels (FT4, TSH, GH, IGF1, FSH, LH, cortisol,ACTH, prolactin) and dynamic testing when necessary.
Results: Our study included 26 women and 10 men with PES. The revealing symptoms were dominated by endocrine signs (52.7%). At least one pituitary hormone deficiency was found in 72% of cases. Secondary adrenal insufficiency was the most common hormonal abnormality (42.85%) followed by hypogonadotropic hypogonadism (34.2%). Central hypothyroidism,mild hyperprolactinemia and central diabetes insipidus were also recorded in 19.4%,19.4% and 5.5% of patients,respectively. Somatotrophic axis was not adequately assessed. The percentage of hypopituitarism in complete PES was significantly higher than that in partial PES (P<0.05).
Conclusion: Our study showed that endocrine alterations are frequent in patients with PES syndrome and that the association of central diabetes insipidus with PES isn’t a very rare event.Moreover, a correlation was found between the residual pituitary gland and the degree of pituitary dysfunction. Thus, a prompt evaluation and an early hormone replacement therapy are always recommended for better quality-of-life.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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