Endocrine Abstracts

Purpose: The purpose of this study were to evaluate the relation thyroid autoimmunity and euthyroid hashimoto thyroiditis in patients diagnosed with pituitary adenoma and association of pituitary adenoma with clinical and laboratory findings

Materials and methods: The retrospective study population included a total of 230 participants. A total of 189 patients (67 with prolactinoma, 35 with acromegaly, 4 with cushing disease and 83 with non-functional pituitary adenoma) were included this study; 41 healthy subjects with similar age and sex and without pituitary adenoma in pituitary MR were used as the control group. This study was conducted at the Erzurum Regional Training and Research Hospital Endocrinology Medicine Clinic and all participants were tested for thyroid autoantibodies.

Results: Body mass index (BMI) (P=0.005, p≤0.001, P=0.027, respectively),waist circumference (WC) (P=0.001, P≤0.001, P≤0.001, respectively), fasting blood glucose (FBG) values (P=0.04, P=0.048, P=0.015, respectively) of the patients with acromegaly were higher and HDL values (P=0.035, P=0.012, P=0.007, respectively) were lower than those of the control, non-functional pituitary adenoma and prolactinoma group. LDL values of the all patients with pituitary adenoma are significantly increased in cases than controls(P≤0.05). Anti-TG (P=0.011) and Anti-TPO (P≤0.001) values were significantly higher in patients with pituitary adenoma compared to healthy subjects values. Anti-TPO and Anti-TG positivity was detected 7.3%, 4.9% in control group, 18.1%, 19.3% in patients with non-functional adenoma, 13.4%, 16.4% in prolactinoma group and 14.3%, 22.9% in acromegaly group. Anti-TG 18.5% positive and anti-TPO 15.9% positive were detected in all patients with pituitary adenoma. The frequency of euthyroid HT was significantly higher in the patients with acromegaly (22.9%), prolactinoma (14.9%) and non-functional adenoma patients (19.3%) than the control group (P=0.006, P=0.037 and P=0.01, respectively). Correlation analysis reveals significantly positive correlation of Anti-TPO (r=0.210; P=0.001) and Anti-Tg (r=0.338; P≤0.001) with pituitary adenoma. The ROC showed that Anti-TPO (AUC=0.66) with sensitivity (58%) and specificity (79.9%) and Anti-Tg (AUC=0.76) with sensitivity (74%) and specificity (74.6%) levels could be used as markers to diagnose pituitary adenoma (P=0.001 and P≤0.001).

Conclusion: Comparing the control group with pituitary adenoma, it was seen that the thyroid autoantibodies were significantly higher in the patient group. In our study, we found a strong association between euthyroid HT and pituitary adenoma and we think that thyroid autoantibodies may play a role in the etiopathogenesis of pituitary adenoma. We think that further, wide-ranging studies are needed.