Endocrine Abstracts

Acromegaly is caused by excessive growth hormone (GH) secretion from pituitary adenomas. Transphenoidal surgery is the first-choice treatment, but new drug therapies (e.g. somatostatin analogs, SSA) offer promising avenues for medical treatment. Complementary diagnostic tools may assist this strategy, helping to refine drug choice. Here, we investigate the associations between postsurgical radiological features and molecular phenotype of pituitary tumors from acromegalic patients and cure acromegaly. This observational study included 17 acromegaly patients (38.4±15.6 yrs; 64.7% women), diagnosed from 2007 to 2012 at the Endocrinology and Nutrition Unit of the Reina Sofia Hospital, in whom surgery, radiology and molecular phenotyping of the adenoma was carried out. Magnetic resonance was performed to localize the tumors, which were all macroadenomas (94.6%) at diagnosis except for 1 microadenoma. Of the 3 patients who met criteria for cure, the postoperative magnetic resonance was normal (p 0.071). There are no differences in postoperative resonance among patients who had been on treatment with SSA. Of the 13 patients treated preoperatively with PFS, 2 had normal and 11 abnormal postoperative MRI (p 0.730). There are no differences in GH, IGF-1 or nadir GH among patients who had normal or abnormal postoperative MRI. GH preoperative in patients with normal MR were 10.50±4.29 ng/dl, IGF-1 754.19±98.97 and Nadir GH 1.69±0.23 ng/dl, in anormal MR were 7.29±8.11, 576.19±295.76 and 7.02±8.36 respectively.

Conclusion: When the postoperative resonance is normal, the healing is significantly greater.