Endocrine Abstracts

Background and aims: The prevalence of metabolic syndrome in Korean youth population has been increased by introduction of Western diet in the past decades. The aim of this study was to investigate the incidence of urinary ketosis and correlation with metabolic indices in healthy adolescents in Korea.

Materials and methods: This was a large-scale, community-based study conducted from January 2007 to December 2010. A total of 1,349 subjects (749 males and 600 females) aged 15 through 19 years without history of diabetes were enrolled. Urine ketone was analyzed by semi-quantitative dipstick method.

Results: The prevalence of urinary ketosis was 24.2% (21.6% in male and 27.5% in female). The presence of urinary ketosis was negatively correlated with fasting glucose, fasting insulin, HOMA-IR, and triglyceride level, and positively correlated with HDL-cholesterol in males (r=−0.086, −0.095, −0.090, −0.084 and 0.100 respectively, all P<0.05), and females (r=−0.124, −0.189, −0.185, −0.141 and 0.134 respectively, all P<0.05).

Conclusion: Urinary ketosis was common in Korean healthy adolescents. Urinary ketosis was correlated with more metabolically healthy profiles in this population.